Three boys, aged 8 months to 4 years old, were living in unsanitary, "squalid" conditions, Zala said.
Heber Gomez, 28, and Nicole Zarei, 27, of the Agatite Avenue address, were charged with one count each of felony possession of a controlled substance and three misdemeanor counts each of endangering the life and health of a child, police News Affairs Officer John Mirabelli said.
Both were found with heroin.
Officers found no food in the home, and police also discovered a substance believed to be heroin, according to a Jefferson Park District lieutenant.
The boys were taken to Our Lady of the Resurrection Medical Center for a health exam and placed in the custody of the Department of Children and Family Services.
Bond information for Gomez and Zarei was not immediately available.
DCFS was not immediately available for comment.