The Chicago Fire Department says the 16-year-old was pronounced dead at Stroger Hospital. The 18-year old was taken to the same hospital for surgery.
Most Chicago public school students just returned to classes yesterday, and already, a 16-year-old sophomore at Bowen High School has been shot to death.
Witnesses reported hearing eight or nine gunshots shortly after school let out at approximately 2:45 p.m. Wednesday.
Police marked a number of shell casings seen in the middle of the intersection at 86th Street and Saginaw where the 16-year-old was shot.
Neighbors called 911 as the shooting continued, and the 18-year-old victim ran down the street.
"I saw one of the guys get shot, and he came up to the car and asked me to help him. Then, he staggered away and his friend was trying to help him, and he fell out there and told his friend he couldn't go no more," one man told ABC7 Chicago.
Souces say the shooting may have been the continuation of a fight that broke out in the cafeteria during lunch at nearby Bowen High School. The 16-year-old victim was wearing his school uniform.
"Might be the beginning...the beginning of another bad time," one man said.
When asked if the recent violence concerned her, one area woman said:
"Yes, because I have teenage daughters. We've been living over here for a couple of years. I worry about it."
On the city's Northwest Side, two more teenagers were victims of gunshots. Police say a 13-year-old and 16-year-old were standing outside in the 2800-block of North Lockwood when someone fired shots from a passing car.
Both of those teens were hit in the leg.
Some parents speculate the violence is an unfortunate byproduct of going back to school.
"We have very few teenagers on this block. That was surprising to me, but with school starting, you have these kind of things happening," said a man who lives near Bowen High School.
Police say they have no suspects in either of the Wednesday shootings.
Last year, 245 Chicago public schools students were shot. Twenty-seven of them died.
On just the second day of the school year, the first student victim of gun violence has already been killed.