Taiwan Smith, 26, is accused of killing two people outside the Victor Hotel nightclub in the 300-block of North Sangamon.
Smith had been thrown out of the club earlier that night in the River West neighborhood, but police say he returned and "just started shooting."
Bouncer Robert Warren, 34, and factory worker Jose Duckins, 30, were both killed in the gunfire, officials said. A third man was wounded.
The Sun-Times Media Wire contributed to this report.