The shooting happened near 40th and King Drive just before 2 a.m.
Police said the 11-year-old boy was in the living room of a home with an 8-year-old and a 12-year-old when a shot was fired.
The 11-year-old was rushed to Comer Children's Hospital with a gunshot wound to his thigh. He is expected to be OK.
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Law enforcement officials later said it appears the 8-year-old accidentally discharged the handgun, hitting the victim.
Police said the investigation into this shooting is ongoing and did not provide further information about the incident.