Urlacher was injured in the first quarter and ruled out of the game at half time.
In a text message sent to the Chicago Tribune Monday, Urlacher said: "season is over."
Urlacher was hurt making a tackle on Packers running back Ryan Grant when he was injured.
The Bears were counting on a healthy Urlacher to help them get back to the playoffs after missing them the past two years. The six-time Pro Bowler appeared to be in better shape after being limited by back and neck problems in recent years.
For many Bears fans who suffered through Sunday night's loss in Green Bay the day after would normally be a little tough. But the loss on the scoreboard combined with the loss for the season of defensive captain and star Brian Urlacher makes it downright devastating for many fans.
Urlacher was the defensive player of the year in the NFL in 2006. This year the ten year veteran was healthy and primed for another great season. And for the first time in his career he had an offense and a quarterback that is also capable of carrying the team. So things were looking up for Bears fans until the injury had Urlacher watching the game from the sidelines during the second half on Sunday night. And then the news came on Monday morning - he's done for the year.
"I wish them the best but I'm hopeful the Bears will move forward and pretty much go to the playoffs," said James Ramos.
Dr. Mark Cohen, a hand and wrist specialist, says the dislocated wrist is one of the worst injuries a player can have, even worse than a broken wrist.
"It's a high energy jury and unusual injury and one which recovers very slowly because the ligaments heal slowly than bone heals after trauma," said Dr. Cohen.
Dr. Cohen says there's no way Urlacher can come back sooner than expected and likely will never regain full use of his wrist.
Bears fans in the meantime are getting a quick education on wrist injuries. It is dominating the conversation on sports talk radio.
Former NFL star John Jurkovic believes all is not lost for the Bears at this point despite losing their defensive captain and leader.
There's things that you can do to bring guys in to play, not up to the level of Brian Urlacher but can play the middle linebacker position in the NFL," said John Jurkovic, ESPN 1000.
There has been talk about possible replacements for Urlacher either on the Bears roster or another roster or free agent. Lovie Smith was noncommital when asked about that during his news conference on Monday afternoon. Fans are hoping they either find someone or the rest of the team will step up or it will be a very long season.
The Associated Press contributed to this report.