Antidepressants work best on patients with severe symptoms

January 6, 2010 A new study in the Journal of the American Medical Association finds individuals with mild to moderate symptoms may fare no better on antidepressants than on a placebo.

But some experts say this doesn't necessarily mean that people with mild to moderate depression should not try antidepressants.

The bottom line is the benefits over time.

Authors of the study say it's important for both patients and health care providers to be aware that antidepressant therapy may not be as beneficial for some.