The man in his 60s is in critical condition.
An investigation is under way into what started the fire.
The victim was found in full cardiac arrest inside a burning home but was resuscitated.
Emergency crews responded to a still-and-box alarm at the 1 1/2 story home at 147 E. 118th Pl. just after 2:10 a.m., Fire Media Affairs Chief Larry Langford said.
A neighbor who called 911 told responders that a person was probably trapped inside, Langford said.
Emergency workers continued to perform advance life-support operations as they transported the man to Roseland Community Hospital, despite the fact that he was not responding, Langford said.
The man was eventually resuscitated at the hospital. He was later transported to Advocate Christ Medical Center in Oak Lawn, Langford said.
Crews extinguished the fire shortly after 2:30 a.m., he said. The fire started in the front of the home.
The Sun-Times Media Wire contributed to this report.