It happened in the 1300-hundred block of North Cleveland on the city's near North Side.
The teenager, who has cerebral palsy, was not hurt.
His 70-year-old father, who arrived at the home during the robbery, was also unharmed. Police say the robbers threatened the father with guns.
The suspects took cash, jewelry and the keys to the family's van.
Police say they are looking for two African American males in their early 20s.