A source confirms to PEOPLE that the couple tied the knot Sunday night at Boone Hall Plantation in Mt. Pleasant, S.C., just outside Charleston.
Lively, 25, is best known for her role as Serena van der Woodsen on the TV show "Gossip Girl." Reynolds, 35, has starred in such films as "Van Wilder," "Green Lantern," "Adventureland," and "The Proposal." He was previously married to actress Scarlett Johansson.