Authorities say the shooting happened just after 2 a.m. in the northbound lanes of the expressway between the 18th Street and Canal Street exits.
Three people were shot. One of them was able to drive the vehicle to the hospital.
A second person in the car died. That victim has been identified as 22-year-old Lavonshay Cooper.
Another man was transported to a hospital in critical condition with several gunshot wounds.
