Chicago police say Akeem Manago was walking with a 23-year-old acquaintance, when four gunmen approached from behind and opened fire.
The 23-year-old was struck in the leg and taken to an area hospital in good condition.
Manago died less than an hour later.
The incident happened just before 2:00 a.m. in the 1300 block of West Hastings.
No one is in custody.