British researchers say these newer drugs such as Seroquel could be linked to a condition called a venous thromboembolism.
Scientists say these drugs were developed to treat psychiatric illnesses but are also prescribed for other conditions such as nausea, vomiting, and vertigo putting many people at risk.
Venous thromboembolism is the overall term for deep vein thrombosis and pulmonary embolism.
Researchers say the increased risk was more marked among new users and those prescribed atypical antipsychotic drugs.
Other drugs that fit this category include Abilify, Solian, Lonasen and Risperdal.
The report is published in the online edition of BMI.