Fourteen-year-old Maya White and her nephew, 3-year-old Elijah Williams, were last seen near Pulaski and Wilson on Chicago's Northwest Side. They were heading to a pizza restaurant.
Family members say Maya is bipolar and has not been taking her medication. She was wearing a peach shirt, jeans and black shoes. Her hair is dark, but she has blonde bangs.
Elijah was last seen wearing a white long sleeve shirt and gray pants. He was pulling a blue plastic wagon.
Friends took to the streets Friday hoping a passerby may have seen the children.
"It's kind of nerve wracking and anxiety builds up, and stuff like that, because it's a child. He is 3 years old. It's sad," said Alexandra Rodriguez, Logan Square Neighborhood Association.
Maya had been staying with her sister, Autumn Bastyr, Elijah's mom.
"He has a twin sister at home that is attached at the hip with him, and she misses him so much. She hasn't stopped asking about him," she said in tears.
Relatives say the children picked up a pizza and were on their way home as Elijah's grandmother followed alongside in a car on Pulaski. But in the block between Sunnyside and Wilson the two children and the wagon vanished.
"We are hoping that she has him somewhere at a friend's house, she's keeping him safe, and hopefully when she sees this she will do the right thing and bring him home, because we just want both of them home," said Brianna Bastyr, Elijah's aunt.
Family members say Maya had recently skipped medication for mental illness and run away while living with her mother in Rogers Park. She was later found in the neighborhood.
"She was good with the kids and she loves them a lot, and that's why I don't understand why she would take him and put him or herself in danger for that matter. I just don't know what she is thinking. I just want her to come home safe and bring him home safe," said Autumn Bastyr.
Anyone who has seen the children should call Chicago police.