The teen was a passenger in a vehicle near the 2400-block of West Cuyler Avenue in North Center just after 10:50 p.m. when someone in a Dodge sedan shot at the vehicle, Chicago police said.
As the victim's vehicle traveled east on Irving Park Road, it crashed in the 4000-block of North Ashland Avenue near Lakeview.
The driver fled on foot, and the teen was taken to Illinois Masonic Medical Center in critical condition, with a gunshot wound to the head, CPD said.
He later died, officials said.
It appeared the two cars were exchanging gunfire, police said. A weapon was found in the victim's vehicle.
This is the second incident in only three days. Janelle Gardiner was killed in a hit-and-run nearby early Sunday morning, after a reported shooting near Irving Park Road and Damen Avenue.
"The 19th police district is going to be ramping up traffic missions, so concentrating on Irving Park, Ashland, and Western corridors looking for license plates of stolen vehicles and making sure we are keeping our community as safe as possible," said 47th Ward Alderman Matt Martin.
Ald. Martin will host a special CAPS meeting next Thursday, Oct. 14, about the two recent incidents.
There is no one in custody, and Area Three detectives are investigating.