Both women will appear in the season premiere of the show, which airs Monday, March 9th, to talk about their injuries.
The were paired with professional dancers Tony Dovolani and Dmitry Chaplin. Further changes in the cast will be announced during Monday's premiere.
"Like most sports, dancing can be a demanding, physical activity. Each participant of 'Dancing with the Stars' warrants in contract that they are physically fit enough to participate in the competition. We love and appreciate Nancy and Jewel's competitive spirit, drive and desire to perform their best. Though we share in their disappointment that they can no longer continue, their physical well-being takes precedent above all else. We thank them both for giving it their all and wish them a quick and full recovery," said Executive Producer Conrad Green in a press release.
"When the doctors told me my injuries were so severe that I couldn't walk, let alone compete, I was devastated that I couldn't continue the show," said Jewel. "I have every intention of being at 'Dancing with the Stars' this season supporting my husband, Ty, and his partner, Chelsie (Hightower). I hope to be back on the show in the future."
"Beyond disappointment doesn't even being to describe how I feel about not being able to continue on 'Dancing with the Stars,'" said O'Dell. "It has been one of my favorite shows since Season One! But I have torn the meniscus in my knee in two places, which requires surgery. 'Dancing with the Stars' was a great experience. I'll miss working with my partner, Tony Dovolani, and all the other wonderful people on the amazing production that is 'Dancing with the Stars'"