Not one player was voted into the shrine in Cooperstown, New York.
Former Cubs slugger Sammy Sosa was one of the famous players left out including Barry Bonds and Roger Clemens.
"For only the eighth time since voting began in 1936, Brian, the voting membership did not elect anyone to Cooperstown," the President of the Baseball Hall of Fame and Museum Jeff Idelson said.
Sosa, Bonds and Clemens have all denied using performance-enhancing drugs despite speculation otherwise.
Sosa's jersey graces a wall at Murphy's Bleachers in Wrigleyville but the announcement surprised none of the patrons.
"I don't think Clemens deserves to be in. I don't think Bonds deserves to be in if you ask me personally. Anybody that's going to have an asterisk next to their name in the record books shouldn't be in the Hall of Fame," Cubs fan Jerry Sutton said.
Clemens, Bonds, and Sosa fell far short of the 75-percent vote threshold needed to make the Hall of Fame.
They received fewer votes than top vote-getter Craig Biggio, the White Sox's Tim Raines and the Cubs closer Lee Smith.
According to ESPN Senior Writer and Legal Analyst Lester Munson, who covered both the Bonds and Clemens perjury trials, there is no question that this is a rebuke.
"Even though Roger Clemens was exonerated by the jury in his criminal trial, obviously baseball writers and people who have followed the story are still thinking that he used these drugs," Munson said.
Hall of Fame inductees are determined by members of the Baseball Writers Association.
Daily Herald sports columnist Mike Imrem cast a ballot and was among the minority who voted to induct Bonds, Clemens and Sosa.
"Teams that won the World Series haven't had the World Series championships taken away from them," he said. "The only thing we eliminate from the history books is who gets in the Hall of Fame. Just doesn't seem right."
"He made his deal with the Devil," Chicago Tribune sportswriter Paul Sullivan said of Sammy Sosa. "Leave him out of the Hall of Fame." This proves the steroid scandals that have plagued baseball have repercussions.
"People who would have been automatic are not going to be automatic anymore if there's any connection between them and performance-enhancing drugs," Munson said.