Blackhawks rookie Brandon Saad scored a short-handed goal early in the third period to snap a 1-all tie.
Chicago (14-0-3) won its fourth straight game to break a mark set by the 2006-07 Anaheim Ducks, who earned points in their first 16 games.
The Blackhawks equaled that run Tuesday with a shootout win over Vancouver.
Saad closed in on left wing one-on-one with San Jose defenseman Brent Burns. After a quick fake, Saad fired a shot from the circle that beat San Jose's Antti Niemi just under the glove 2:24 into the period.
Viktor Stalberg also scored for league-leading Chicago, which has captured a total of 31 of 34 possible points.