Police say one man was killed in a shooting on the city's South Side in the Chatham neighborhood.
On the West Side Austin neighborhood, police say a 40-year-old man was shot and killed.
At least ten other people were wounded in shootings elsewhere in the city, including three people on the South Side.
One of the shootings took place near Roosevelt and South Kolin Avenue, where three people were seriously injured. Police say one of the three victims, a 27-year-old woman, was shot in the face and was hospitalized in grave condition Saturday evening. The other victims were shot in the back and the arm.
No arrests had been made as of 5 p.m. Saturday.