Amtrak train 58 derailed at 9:30 a.m. The train was close to Chicago's Union Station at the time of the incident.
Shuttle buses transported passengers to Union Station, and no one was injured, authorities said.
The derailment blocked the tracks through the morning hours and caused a few cancellations for trains on Metra's Rock Island District line.
Because of the track obstruction caused by the derailment, Metra's Rock Island trains were blocked from entering and exiting the LaSalle Street station for a few hours. A few trains on Metra's Rock Island line have been delayed and trains No. 214 and 209 will not operate Sunday because of the track obstruction, according to Metra.
The train left New Orleans on Saturday, Amtrak spokeswoman Christina Leeds said. The train was heading to Union Station when, at 9:30 a.m., the wheels of the locomotive "lost contact with the track," around 18th Street, between Clark and Canal streets, she said. The train remained upright, she said.
The CTA was honoring Metra passes for commuters between LaSalle Street station and their 35th Street station on the Green Line, Metra said. This allows Metra commuters to board trains from the Lou Jones station, which is one block from the CTA Green Line 35th Street station.
The derailment occurred on tracks owned by Canadian National near a CSX lift bridge, Leeds said.
By 1:00 p.m. the area had been cleared. Trains could be seen moving normally through the tracks Sunday afternoon, but authorities remained on the scene.
The Sun-Times Media Wire contributed to this report.