Two other people escaped safely on their own.
The fire broke out in the one-story bungalow in the 9000-block of South Woodlawn just before dawn.
Firefighters discovered two women in a back bedroom. They passed one woman through a window into the arms of a fire chief. The second woman was in a hospital bed. They had to wait until the fire was extinguished before they could get her out of the house.
Investigators are trying to determine what caused the fire.
