Firefighters discovered a body in a burned-out room on the third floor of the hotel. Officials have identified the victim as 45-year-old Minnette Edmon of Joliet.
Two people suffered minor injuries in the blaze. They are expected to be OK.
Firefighters from surrounding communities spent three hours dousing the brick building to get the fire under control. The building was gutted.
"It's been a while since we have had something like this, but we're ready. Everybody else was ready. We had a lot of help. We have a lot of friends in the neighboring communities that come down and give us a hand," said Rob Cronholm, Lockport Fire Chief.