Police in Gary, Ind., are asking for help as they search for the person who pulled the trigger just after midnight Sunday morning.
A man was also wounded in the shooting.
The boy was inside a home in the 1000-block of Durbin Street in Gary when the gunfire began.
Seven-year-old Leonard Cobbs III is in critical condition after bullets shattered a family holiday gathering. Witnesses say the boy was enjoying the early minutes of Christmas day at the home of one of his cousin's friends when the unthinkable happened.
"It was a family gathering, Christmas the next day, the kids playing video games, and the adults just sitting, talking," said Dwayne Millender, the victim's cousin.
Millender described how Christmas began for his family after a drive-by shooting left his little cousin critically wounded.
Relatives say the 7-year-old remains hospitalized with a gunshot wound to his head.
The shooting happened just after midnight Sunday morning as the boy, his mother and others celebrated the holiday at a friend's home.
Several neighbors say they called 911 after hearing what sounded like firecrackers.
"I heard the shots. I heard, like, a series of shots, maybe about 10 or 15, and then I woke up and was like, Wait a minute, that was too much," said neighborhood resident Evelyn Jones.
Officers arrived to find Leonard in the living room and another victim, a 36-year-old man, also wounded in the kitchen.
Cobb was taken to Gary Methodist Hospital, and then airlifted to a Chicago hospital, where he remains in critical condition in the pediatric intensive care unit.
Police do not have a motive for the shooting, including whether it was gang or drug-related, or whether the two shot were the intended targets.
"We really don't have a whole lot of concrete evidence…as far as leads, every little lead we have, we're going to follow up on," said Gary Police Corporal Gabrielle King.
In the meantime, concerned relatives are just praying for Leonard to get better.
"I don't understand why this happened to him," said Millender.
The other victim is in stable condition at a Gary hospital with a gunshot wound to the upper thigh.
Four other adults inside the home at the time of the attack were unharmed.
No arrests have been made. Gary police want the public's help and are asking anyone with any information about the shooting to contact them immediately.