The Chicago Fire Department says they removed 2-year-old Jaquin Roby from a front bedroom.
He was rushed to Holy Cross Hospital where he was pronounced dead.
Neighbors and friends have left toys outside the home in memory of Jaquin.
"He was a lively little fellow. He thought he was a big man," family friend Dororthy Jones said. "[He would] just walk up and down the street. He made friends with everybody."
There were no other injuries reported.
Authorities are investigating the cause of the fire.