West Lake Street in Bartlett was closed for several hours while police investigated.
A 46-year-old man in a car died in the head-on collision with a pickup.
At about 8 a.m., a 1992 gold Ford Taurus was eastbound on U.S. 20/Lake Street between Naperville Road and Lambert Lane, when it crossed into the westbound lanes and struck a 2002 GMC Sonoma head-on, a release from Bartlett police said.
The 46-year-old man driving the Taurus was taken to St. Alexius Medical Center in Hoffman Estates by the Bartlett Fire Protection District and later pronounced dead, police said. The 26-year-old man driving the Sonoma was also taken to St. Alexius with non-life-threatening injuries.
The Sun-Times Media Wire contributed to this report.
