The shooting occurred about 9:20 p.m. in the 11600-block of South Prairie Avenue. The boy was transported to Christ Hospital in critical condition, but later died.
Police are still investigating what happened.
No one is in custody.
A 17-year-old boy was also fatally shot Saturday in Austin on the West Side.
RELATED: No charges yet filed in girl's East Garfield Park stabbing death; grandfather claims mother is suspect
The victim was in the alley in the 200-block of North Leamington Avenue around 11:10 a.m. when he was approached by two unknown suspects who proceeded to fire shots at him, Chicago police said.
After the victim was struck in the upper torso, the two gunmen got into a light-colored vehicle and fled southbound on Leamington Avenue, police said.
The 17-year-old was pronounced dead on the scene.
A 5-year-old girl was stabbed to death Saturday morning in East Garfield Park. Her mother is a suspect in the case, according to a relative.
Twenty four people had been shot and seven killed as of early Sunday morning in Chicago weekend violence.
Sun-Times Media contributed to this report.